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BerichtGeplaatst: 12-11-2018 04:55:20    Onderwerp: ur hands dirty and try Reageren met citaat

WASHINGTON Air Jordan 13 DMP For Sale , May 26 (Xinhua) -- Researchers from the United States and the Netherlands said Tuesday they have identified Ebola 's Achilles' heel that could be targeted to completely block the deadly virus's infection.


The researchers reported in the online U.S. journal mBio that Ebola can't infect mice unless it first attaches to a host protein called Niemann-Pick C1 (NPC1).


"Our study reveals NPC1 to be an Achilles' heel for Ebola virus infection," co-study leader Kartik Chandran, associate professor of the Albert Einstein College of Medicine of Yeshiva University, said in a statement.


"Mice lacking both copies of the NPC1 gene, and therefore devoid of the NPC1 protein Air Jordan 13 History of Flight For Sale , were completely resistant to infection. "


Previous in vitro studies have demonstrated that Ebola enters host cells by binding directly to NPC1, and that blocking the ability of the virus to engage NPC1 prevents Ebola infection.


To test whether this was also true in vivo, the team exposed three types of mice to Ebola: wild-type or normal mice, "knockout mice" that were genetically engineered to be completely deficient in NPC1, and "carrier mice" engineered to have both a normal and a mutant NPC1 allele.


While the wild type mice succumbed to the infection Air Jordan 13 Heiress Velvet For Sale , the " knockout mice" were entirely free of virus replication and completely protected against the disease, they found.


"Carrier mice" initially had high levels of Ebola viremia, but the levels quickly decreased as the host immune response effectively cleared the virus.


"The underlying story of an Ebola infection is that your immune system and the virus are in a race," said co-study leader John Dye, branch chief of viral immunology at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID).


"If you can do anything to control the amount of virus that is in the system Air Jordan 13 Low Pure Platinum For Sale , keep it below a certain threshold, your immune system in many cases will win that race."


NPC1 helps transport cholesterol within the cell. People lacking NPC1 due to genetic mutations develop a fatal neurodegenerative disorder called Niemann-Pick disease, which is sometimes referred to as childhood type of Alzheimer's disease.


Even though such a treatment in humans would also block the cholesterol transport pathway, "we think patients would be able to tolerate the treatment, which would be needed for only a short time Air Jordan 13 Low Brave Blue For Sale ," said Andrew Herbert, senior research scientist in the viral immunology branch at the USAMRIID, and co-first author of the study.


The team hoped that future research in humans could lead to the development of antiviral drugs that can effectively target NPC1 and prevent infection by Ebola and other highly virulent filoviruses, which also require NPC1 as a receptor.


Currently, there are no approved treatments for Ebola Air Jordan 13 Low Chutney For Sale , and all of the therapies in the drug pipeline focus on attacking the virus. Targeting NPC1 is the first host-based therapeutic approach.




HO CHI MINH CITY, Nov. 3 (Xinhua) -- Vietnam has just detected five new Zika patients in Ho Chi Minh City, increasing the total in the city to 22, and the total in the country to 28, the municipal Health Department said Thursday.


The municipal authorities plan to announce on Thursday afternoon the establishment of a steering committee on preventing and fighting against Zika outbreaks.


If Ho Chi Minh City continues to spot new Zika cases, it will announce Zika outbreak at municipal level, not at communal level as currently.


People in the city can now go to 30 hospitals to have their blood tested for Zika virus free of charge.


Other Zika patients in Vietnam are from Phu Yen, Khanh Hoa, Binh Duong, Long An and Dak Lak provinces.

"

PARIS, Nov. 25 (Xinhua) -- French professional soccer's governing body, the LFP, have decided to bring the 2015 Trophee des Champions back to Montreal, Canada where the campaign was firstly held abroad.


The French top-flight's traditional curtain-raiser Air Jordan 13 Hyper Pink For Sale , featuring the previous season's Ligue 1 champions and that yera's Coupe de France winners, was staged outside of France for the first time in 2009 in Montreal.


It will come back to the Quebec city, at the Saputo Stadium on Saturday 2nd August 2015.


""The LFP decided to stage the game in Montreal once more as football is rapidly developing in Canada, which will host the women's World Cup between 6-15 July next year,"" reported the French soccer's website www.ligue1.


Established in 1995 Air Jordan 13 Flint For Sale , the Trophee des Champions has also been staged in three African cities, Tunis, Tangiers, Libreville, as well as New York and Beijing since 2009.

"

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Whether you enjoy a little personal time, or socializing with friends with common interests Air Jordan 13 Altitude Black 2017 For Sale , you will enjoy gardening for both aspects. Networking with other gardeners is also a great idea because you can ask questions about things you are unsure of and get prompt answers. Never be afraid to ask questions, especially if you are in a nursery or gardening facility where the people that are there are more than likely gardeners themselves. You may want to join a club or group in your area that’s devoted to gardening. Community centers that are devoted to gardening are a great place to meet others with similar interests and perhaps more knowledge. Gardening is not limited to your area, but is a worldwide phenomena which the Internet allows you to access the minds of other gardeners everyday.


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